−11.5%
Plaque reduction
Nothing synthetic. No drugs. A pure enzyme extracted from a real food.
Today Only: 3-Month Supply — Save 49%
Cold hands.
Sudden dizziness.
Swollen ankles.
These aren't three different problems. They're three stages of the same one. The question is — what stage are you at?
All three symptoms — all caused by plaque buildup in your arteries.
★★★★★
"My cardiologist was stunned."
I had cold feet, dizziness, and my ankles were starting to swell. 3 months on this — all three are gone. — Eric T., 58 · Texas
Break Down Artery Plaque 36%●
Lab Tested Every Batch●
60-Day Money Back Guarantee●
5,000 FU Per Capsule●
Non-GMO Japanese Soy●
Buy 2 Get 1 Free●
Lab Tested Every Batch●
60-Day Money Back Guarantee●
5,000 FU Per Capsule●
Non-GMO Japanese Soy●
Break Down Artery Plaque 36%●
Lab Tested Every Batch●
60-Day Money Back Guarantee●
5,000 FU Per Capsule●
Non-GMO Japanese Soy●
Buy 2 Get 1 Free●
Lab Tested Every Batch●
60-Day Money Back Guarantee●
5,000 FU Per Capsule●
Non-GMO Japanese Soy●
The Warning Stages
Three symptoms. One root cause.
Catch it early and it's reversible. Wait too long and it puts you at real risk of a heart attack or stroke. Here's what to look for — and where you might already be.
Stage 01
The earliest sign — and the one most people ignore
Cold hands. Cold feet.
This is your circulation slowing at the extremities. The blood is still flowing — but not fast enough to keep the smallest vessels warm.
It happens when the inner walls of your arteries start to harden. A thin layer of plaque begins growing. Small enough to ignore. Big enough to slow everything down.
Most people put on thicker socks and forget about it. That's the mistake.
Stage 02
Now your heart is having to work harder
Dizzy when you stand up.
This is more serious. Your heart is now working harder to push blood up to your brain — and when you change position fast, it can't keep up.
By this stage, the plaque has thickened. Your arteries have lost their flexibility. And your blood pressure has started climbing — without you noticing.
Most people blame age, dehydration, or "standing up too fast." It's none of those things.
Stage 03
The stage most people ignore — and the most dangerous
Swollen ankles.
This is the one most people ignore. It's also the most dangerous.
By the time fluid is collecting in your legs, your heart is under serious strain. Your arteries are stiff enough that blood is pooling instead of circulating.
This is the stage that puts you at real risk of a heart attack or a stroke.
Don't wait until stage 3Whichever stage you're at, the cause is the same: plaque buildup and stiffening arteries.
For over a thousand years, the Japanese have had a way to reverse it.
See the solution →
5,000FU
Per capsule
Meet Nattokinase
The Japanese enzyme that breaks down plaque.
Extracted from natto — a traditional fermented soybean dish eaten in Japan since the 11th century. The regions that consume it daily have some of the lowest cardiovascular disease rates on earth. It is not a coincidence.
-
✓
100% natural
-
✓
Breaks down plaque naturally
Dissolves the fibrin holding existing plaque together — letting your body clear it out gradually.*
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✓
Consumed in Japan for over a thousand years
Eaten daily since at least the 11th century. A long, well-established history of safe use.
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✓
Proven in multiple clinical studies
Including a 12-month randomized controlled trial showing up to 36% plaque reduction.*
How It Works
The cause, the solution, the result.
The Cause
Plaque builds up
A sticky protein called fibrin accumulates in your arteries. It hardens into plaque. Blood flow slows. One day a chunk breaks off — and that's a heart attack or stroke.
The Solution
Nattokinase
A natural enzyme from a Japanese food called natto. It breaks down the fibrin that holds plaque together — helping your body clear clots before they form.*
The Result
Real results
Up to 36% less plaque. 13 mmHg lower blood pressure. 33% lower stroke risk. Published in real clinical studies. Not marketing.*
Scientific Studies
Real studies. Real numbers.
Nattokinase has been tested in thousands of people across peer-reviewed clinical trials. Here's what they found.
10,800 FU/DAY
Reduced artery plaque & cholesterol
Artery plaque reduction
Up to 36%
LDL cholesterol improved
84.3% of participants
HDL cholesterol improved
89.1% of participants
Artery wall thickness dropped from 1.33 mm to 1.04 mm. The lower dose of 3,600 FU/day was ineffective.
doi.org/10.3389/fcvm.2022.964977 →
6,000 FU/DAY
Reduced artery plaque
Plaque reduction (NK vs control)
−36.6% vs −11.5%
Plaque area decreased from 0.25 to 0.16 cm², artery thickness from 1.13 to 1.01 mm.
doi.org/10.3760/cma.j.issn.0376-2491.2017.26.005 →
5,000 FU/DAY
doi.org/10.3390/nu15194239 →
Reduced cholesterol levels
Total cholesterol (NK vs placebo)
−13.75 vs −4.16 mmol/L
Scan To Verify
100%
Of batches tested
Transparent Testing
Every bottle has a QR code. Scan it. See the lab report.
Most supplement brands test their products once a year — if they test at all. We test every single batch at an independent third-party lab. Then we put a QR code on the bottle that opens the public lab report for that exact batch. No tricks. Just proof.
01
Find the QR code on your bottle
Printed next to the batch number on the back of every bottle we ship.
02
Scan with your phone camera
Opens the certificate of analysis from SORA Labs — an independent ISO 17025:2017 accredited laboratory.
03
See exactly what's inside
Verified potency, heavy-metals tested, identity confirmed. The same report we keep on file. Anyone can view it.
ISO 17025:2017 Accredited Lab
Heavy Metals Tested
Potency Verified
Identity Confirmed
Doctor Recommended
Hear it from the doctors.
Leading medical doctors are now recommending Nattokinase as a first line of defense for heart health.
⚕
Clinician Reviews
⚕
Independent Clinician Evaluations
Clinicians receive product samples and are never compensated to submit evaluations.
CW
Dr. Chit Wong, MD
Verified clinician
- Specialty
- Primary Care
- Years in practice
- 27
Capsules target plaque-related proteins to support cardiovascular health
As people age, their arteries may stiffen, which can negatively influence blood pressure and blood flow. Plaque buildup can sometimes make this problem worse by further narrowing blood vessels. This formula contains an enzyme called nattokinase that has shown promise supporting more flexibility in the arteries. Nattokinase can specifically target excess proteins that are known to contribute to plaque. Breaking down these proteins may encourage blood vessel pathways to stay more open over time. The research in this area is still developing. However, the results I have seen make me optimistic about nattokinase for cardiovascular support.*
📄 Frontiers in Cardiovascular Medicine +1
Highlights:
Flexible arteries
Aids blood-flow
Aging support
MK
Dr. Matthew Kelly, MD
Verified clinician
- Specialty
- Family Medicine
- Years in practice
- 14
Nattokinase works to remove proteins linked to clotting
Your body naturally makes clotting proteins to help with healing, but those proteins can put extra pressure on your heart and blood vessels when levels get too high. Nattokinase may help the body keep those proteins in check and promote normal vessel function and circulation. A clinical trial published in Nutrition Research showed that participants who regularly took nattokinase saw reductions in proteins linked to excessive clotting. It's encouraging to see positive research showing how nattokinase could benefit important cardiovascular functions. I would say, if you are a patient who needs additional cardiovascular support, this formula can be a strong option.*
📄 Nutrition Research +1
Highlights:
Removes excess-proteins
Normal circulation
Cardiovascular function
Order Now
Clinician reviews powered by frontrowMD
†Larger-scale research to support these product claims is still developing.
The Inbox
People won't stop messaging us.
Raw, unedited messages from real customers. Every week. Every day. We publish them as we get them.
Real People · Real Hearts
Join 100,000+ people already taking it.
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Nattokinase Arterial Support Capsules
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Real Customers · Real Results
People who actually feel the difference.
★★★★★
"My doctor was shocked."To be honest, this product is profoundly effective. My doctor was surprised by the drop of my cholesterol reading. I'm ordering more today.
B
Brigitte M. · FL✓ Verified buyer
★★★★★
"Cold feet — gone."My hands and feet used to be ice cold all the time. After 3 weeks on this they're warm again. First thing my wife noticed.
J
Jason K. · TX✓ Verified buyer
★★★★★
"No more dizzy spells."I was getting dizzy every time I stood up. 6 weeks in — gone. My BP is down 14 points and I feel 10 years younger.
L
Linda W. · CA✓ Verified buyer
★★★★★
"Ankle swelling stopped."My ankles used to puff up every evening — I almost couldn't walk by 8pm. After 6 weeks on this it just... stopped. Subscribed.
P
Patricia W. · WA✓ Verified buyer
★★★★★
"Stopped the statins."I was struggling with bad side effects from prescription statins. This product is helping me support healthy cholesterol without them. Huge difference.
J
John C. · OH✓ Verified buyer
★★★★★
"Heart surgery upcoming — surgeon is happy."I've just ordered my 2nd batch. I'm due heart surgery in the coming weeks and my surgeon is happy with my blood flow and cholesterol.
C
Christine C. · AZ✓ Verified buyer
★★★★★
"Quietly impressed."After 6 weeks on the 5,000 FU tablets I can breathe more easily and don't get out of breath so quickly. It's noticeable.
N
Nick R. · GA✓ Verified buyer
★★★★★
"Worth every penny."You're paying for honesty, which is rare in supplements. Circulation improved, blood pressure down, no gut issues. I recommend to everyone I know.
M
Marcus J. · WA✓ Verified buyer
Common Questions
Things people ask us.
I've got cold hands and feet. Could this really help?
Cold extremities are stage one of arterial stiffening — your circulation is slowing because the inner walls of your arteries are starting to harden. Nattokinase supports the body's ability to clear the fibrin behind that buildup. Most customers notice their hands and feet warming up within 3–6 weeks.*
How long does it take to see results?
Some people feel a difference in a few days — less swelling, better circulation, support for healthy blood pressure. The bigger benefits take longer. The studies showing plaque support ran for 6 to 12 months. That's why we offer bigger discounts on longer supplies.*
What is Nattokinase?
Nattokinase is a natural enzyme. It comes from natto — a traditional Japanese food made from fermented soybeans. The enzyme supports the breakdown of fibrin, a sticky protein that can build up in your arteries. It works with your body's own systems, but talk to your doctor first if you're on medication.*
How do I know yours has what the label says?
Every batch is tested by an independent third-party lab (SORA Laboratories, ISO 17025:2017 accredited) before it ships. Not once a year. Every batch. And every result is published online. You can pull up the report for your exact bottle right now. We're one of the only brands in the country that does this.
Are there any side effects?
Nattokinase is generally well-tolerated by most adults at recommended doses. However, it has blood-thinning properties. Do not combine it with blood thinners like warfarin, aspirin, or fish oil without your doctor's approval. Some people experience mild stomach upset or headaches. Do not take it if you have a bleeding disorder, upcoming surgery, or if you are pregnant or breastfeeding. Always consult your healthcare provider before starting any new supplement.
Can I take it with my medication?
Always check with your doctor first — especially if you're on blood thinners, aspirin, or heart medication. They can confirm whether it's appropriate for your situation.
How should I take it?
One capsule a day, on an empty stomach. First thing in the morning or last thing at night works best. Food can interfere with absorption.
Where is it made? How does shipping work?
Our nattokinase is manufactured and packed in our own GMP-certified facility in the UK, just outside Oxford. We then ship inventory in bulk to our Texas fulfillment center, which handles every US order. So you get fast, domestic US shipping with no customs, no duties, and no import fees — the same product that ships to UK customers, only delivered locally.
How long does shipping take?
US orders ship from our Texas warehouse and typically arrive in 3–5 business days. We dispatch the same day or next business day. You'll get tracking emailed as soon as your order leaves the warehouse. Free shipping is included on the 90-day plan.
What if it doesn't work for me?
You're covered by our 60-day money-back guarantee. Not satisfied? Email us and we'll refund you. No forms, no return shipping, no fight.
The Full Research
Seven studies on Nattokinase.
Every major clinical trial and observational study — with full data, dosage, duration, and source. Peer-reviewed and published.
10,800 FU/day
Study 01
Reduced artery plaque & cholesterol
% of Participants Who Improved
Artery Health — Before vs After 12 Months
Before
1.33 mm
Artery wall thickness
→
After
1.04 mm
Artery wall thickness
Baseline
100%
Plaque size
→
After
−36%
Plaque size
After 12 months of daily nattokinase supplementation, 95.4% of participants showed significant improvement in total cholesterol, 85.2% in triglycerides, 84.3% in LDL "bad" cholesterol, and 89.1% in HDL "good" cholesterol. Carotid artery wall thickness dropped from an average 1.33 mm to 1.04 mm, and plaque size decreased by up to 36%. The lower dose of 3,600 FU/day was ineffective — the benefits only appeared at 10,800 FU/day, challenging the commonly recommended dose of 2,000 FU/day.*
doi.org/10.3389/fcvm.2022.964977 ↗
Dietary Natto
Study 02
Reduced risk of cardiovascular mortality
Highest vs Lowest Natto Intake — Mortality Risk
−25%
Cardiovascular mortality
−31%
Stroke death (all types)
−33%
Ischemic stroke death
Researchers followed 13,355 men and 15,724 women (avg. age 55) for 16 years. Participants were stratified by daily natto intake (approximately 0, 1.4, 2.7, or 7.3 g/day). Those in the highest intake group had a 25% lower risk of cardiovascular mortality, a 31% lower risk of stroke death, and a 33% lower risk of ischemic stroke death — the clot-driven kind. The effect was independent of overall soy intake.*
doi.org/10.3945/ajcn.116.137281 ↗
6,000 FU/day
Study 03
Reduced artery plaque
Plaque Reduction — Nattokinase vs Control
Control Group
Nattokinase Group
−36.6%
Plaque reduction
After 26 weeks, the nattokinase group showed a significant reduction in both plaque area and artery wall thickness. Plaque area dropped from 0.25 to 0.16 cm², and artery wall thickness from 1.13 to 1.01 mm — a 36.6% reduction vs 11.5% in the control group.*
doi.org/10.3760/cma.j.issn.0376-2491.2017.26.005 ↗
5,000 FU/day
Study 04
Reduced cholesterol levels
Total Cholesterol — 120 Day Change (mmol/L)
Placebo
−4.16
mmol/L change
Nattokinase
−13.75
mmol/L change
Over 120 days, the nattokinase group saw total cholesterol drop by −13.75 mmol/L vs just −4.16 mmol/L for placebo. LDL "bad" cholesterol fell by −12.82 mmol/L in the nattokinase group — while the placebo group's LDL actually rose by +1.83 mmol/L.*
doi.org/10.3390/nu15194239 ↗
4,000 FU/day
Study 05
Reduced clotting protein levels
Three key blood-clotting proteins were tracked across three populations: healthy adults, cardiovascular patients, and dialysis patients. After two months of nattokinase, fibrinogen dropped 7–10%, Factor VII fell 7–14%, and Factor VIII fell 17–19% across all groups.*
doi.org/10.1016/j.nutres.2009.01.009 ↗
3,615–3,662 FU/day
Study 06
Nattokinase + red yeast rice for cholesterol
The group taking nattokinase combined with red yeast rice showed significant improvements: triglycerides fell −0.39 mmol/L, total cholesterol −0.66 mmol/L, diastolic blood pressure dropped −7.39 mmHg, and HDL "good" cholesterol rose +0.195 mmol/L.*
doi.org/10.3389/fnut.2024.1380727 ↗
1,200 FU/day
Study 07
Stroke recovery support
Highest Level of Functional Recovery
Control Group
13.3%
Of patients
Nattokinase Group
61.3%
Of patients
After 60 days of treatment, 61.3% of stroke patients taking nattokinase reached the highest level of functional recovery, vs just 13.3% in the control group. Common post-stroke symptoms (headache, dizziness, fatigue, poor sleep) improved more in the nattokinase group.*
doi.org/10.1089/jmf.2019.0183 ↗