Nattokinase is a natural enzyme produced during the fermentation of soybeans into natto, a traditional Japanese food that has been consumed for over 1,000 years. It was first discovered by Japanese researcher Dr. Hiroyuki Sumi in 1987.

Despite its name, nattokinase is actually a serine protease enzyme — not a kinase. It's best known for its fibrinolytic activity, meaning it has the ability to break down fibrin, a protein involved in blood clotting that is also found in arterial plaque. This is what makes nattokinase different from most other natural cardiovascular supplements.

Nattokinase works primarily by breaking down fibrin — the protein that helps blood clots form and that binds arterial plaque together. It also supports your body's own natural fibrinolytic system by promoting the production of t-PA (tissue plasminogen activator), your body's built-in clot-dissolving enzyme.

Think of it this way: if plaque buildup is what narrows your arteries over time, nattokinase is the enzyme that helps your body's natural ability to keep them clear. Research suggests it may support healthy blood pressure levels, improve circulation, help prevent excessive clotting, and support arterial flexibility.

Natto is the whole fermented soybean food. Nattokinase is the specific enzyme extracted from natto. There are several practical differences:

A 50g serving of natto contains only about 1,500 FU of nattokinase. To match our 5,000 FU dosage, you'd need 3–4 packs of natto daily. Natto also has a strong smell and sticky, slimy texture that most people outside Japan find unpleasant. It's also hard to find fresh natto outside of Japan, and there's no way to know exactly how much active enzyme you're getting per serving.

Our supplement delivers an exact, measured dose in every capsule — no taste, no smell, no guessing. It's also less vulnerable to stomach acid degradation than the enzyme found in whole natto. Additionally, natto contains significant vitamin K2, which can interfere with blood-thinning medications like warfarin, whereas our nattokinase supplement has vitamin K2 removed.

A clinical study of 1,062 participants published in Frontiers in Cardiovascular Medicine (Chen et al., 2022) found that nattokinase supplementation at 10,800 FU/day for 12 months led to a 36% reduction in arterial plaque size, reduced carotid artery wall thickness from 1.33 mm to 1.04 mm, and significant improvements across all key cholesterol markers — with over 95% of participants showing improvement in total cholesterol.

Separately, a major 2023 meta-analysis combining 23 clinical trials and over 7,400 patients found that even just a 1% reduction in plaque volume reduced the risk of heart attack by up to 25%, stroke by 20%, and cardiovascular death by 14%.

This is one of the most common questions we get. When fibrin is broken down and arterial buildup is loosened, the tiny fragments enter your bloodstream as microscopic particles. From there, your body's built-in filtration system takes care of the rest. Your liver processes and neutralises the debris, and your kidneys filter it out. It's the same natural system your body already uses every day to keep your blood clean.

We offer nattokinase at 5,000 FU per capsule. FU stands for "Fibrinolytic Units" — it's the standard measurement for nattokinase enzyme activity. The more FU, the more fibrin-dissolving power per dose.

Clinical research has used dosages ranging from 2,000–10,800 FU/day. Our 5,000 FU capsule is designed for daily cardiovascular maintenance. For those seeking more targeted support in line with the 12-month clinical study, two capsules per day (10,000 FU) more closely matches the 10,800 FU/day used in the research that showed 36% plaque reduction.

Our Nattokinase Artery Support contains nattokinase as the primary active ingredient, combined with Motherwort and Oregano — both of which have traditional and emerging research supporting their benefits for heart and artery health. The formula is designed to work synergistically for comprehensive cardiovascular support.

There were two key reasons. First, many customers already take Vitamin K alongside their Vitamin D supplement, so they were getting a double dose — and we received a number of complaints about this. Second, and more importantly, nattokinase supports healthy blood flow while Vitamin K is a clotting agent. Vitamin K is essential for making proteins like prothrombin that help your blood clot properly. So having both in the same capsule is somewhat counterproductive — one does one thing and the other does the opposite.

Vitamin K2 is great for artery health on its own, but we didn't think it made sense to include it in the same supplement. Vitamin D3 + K2 is a very affordable standalone supplement, and those who want to take it alongside our nattokinase easily can.

Take one capsule daily with water. It can be taken with or without food. For those seeking higher-dose support in line with the clinical research (10,800 FU/day), two capsules per day can be taken. Consistency is key — the studies that showed the most significant results involved daily supplementation over 12 months without breaks.

Let's be honest — you probably won't feel any different during the first 1–3 months. That's completely normal. Behind the scenes, nattokinase is actively working to stabilise existing plaque and support your body's natural fibrinolytic processes. The foundation is being built.

Around month 4, some users begin noticing improved circulation, better energy levels, and warmer extremities. By month 8, the benefits are more pronounced — sharper mental clarity, stronger exercise performance, and sustained energy. The full payoff comes at month 12, which is the timeframe used in the clinical study that showed a 36% reduction in arterial plaque.

We strongly recommend getting bloodwork done at month 3 to track your ApoB and LDL cholesterol levels. These markers will show measurable improvements before you feel a physical difference — and they're your proof that it's working.

Nattokinase Artery Support is made from natural ingredients and is generally well-tolerated. Nattokinase has been studied in clinical trials with dosages up to 10,800 FU/day for 12 months with no significant adverse effects reported.

However, if you are taking blood-thinning medications (such as warfarin, aspirin, or other anticoagulants), are pregnant or breastfeeding, have a bleeding disorder, or are scheduled for surgery, you should consult your healthcare provider before starting any new supplement. If you have any pre-existing conditions or concerns, always speak with your doctor first.

If you're taking any medication — especially blood thinners, anticoagulants, or blood pressure medication — please consult your healthcare provider before adding any supplement, including nattokinase. Your doctor can advise you on whether it's appropriate for your specific situation and whether any dosage adjustments to your existing medication may be needed.

Every single batch we produce is sent to an independent third-party laboratory for testing. They test for dosage accuracy, identity verification, heavy metals, and microbiological safety. We publish 100% of the results — nothing hidden, nothing edited.

Every bottle ships with a scannable QR code. Scan it, and you'll see the exact test results for your specific batch. Not a generic certificate. Not a stock photo of a lab. The actual results for the actual bottle in your hand.

We manufacture everything in-house at our own GMP-certified facility. GMP stands for Good Manufacturing Practice, and it means every step of our process — from raw ingredient intake through to bottling — follows strict quality and hygiene standards. We control the entire production chain. Nothing leaves our facility unless we're confident it's exactly what the label says it is.

Our founder, Logan, has independently tested nattokinase products from other brands and found that 80% failed to meet their label claims. That's not a typo — 8 out of 10 bottles didn't contain what they said they did.

Natural Foundation was built specifically to solve this problem. We manufacture in-house, test every batch with independent labs, and publish every result publicly. We also have 219 clinicians who recommend our nattokinase — without compensation, sponsorship, or being asked. They recommend it because the quality speaks for itself. On top of that, we have 120,000+ customers and 2,400+ verified reviews with a 4.8/5 rating.

We offer several options to suit different commitments:

Subscribe & Save (recommended): 6-month supply at $159.99 (save 46% — just $20.67/mo with free shipping), 3-month supply at $89.99 (save 39% — $30.00/mo with free shipping), or 1-month supply at $39.99/mo (save 20%).

One-time purchase: 6-month supply at $199.98 (most popular), 3-month supply at $149.99, or single bottle at $49.99 + shipping.

All subscriptions can be paused or cancelled anytime — no lock-in contracts.

All US orders ship from our warehouse in Texas. We dispatch all orders the same day or the next working day. Standard shipping typically reaches anywhere in the United States in 2–5 business days, depending on your distance from Texas. We offer free standard shipping on all orders over $100.

We offer a 30-day money-back guarantee on your first order. If you're not satisfied, you can return the product within 30 days of receiving it for a full refund (minus shipping costs). If you purchased more than one bottle, the remaining bottles must be returned unopened. Return shipping is the customer's responsibility.

If you receive a defective or incorrect product, we'll replace it at no extra cost to you — just contact our support team.

When you subscribe, your chosen supply is automatically shipped to you on a recurring basis so you never run out or miss a dose. You'll save up to 46% compared to one-time purchases, and subscription orders include free shipping.

You can pause, skip, or cancel your subscription at any time — there are no lock-in contracts, no hidden fees, and no cancellation penalties. We want you to stay because it's working, not because you're stuck.

Because the clinical research that showed a 36% reduction in arterial plaque ran for 12 months. The participants who got those results didn't skip days, didn't take breaks, and didn't give up during the stabilisation phase when nothing seemed to be happening.

If you buy one bottle, take it for a month, and don't feel anything different, you'll probably stop — and that's exactly the problem. Subscribing removes the friction: your next bottle arrives before you run out, you never break the chain, and you give your body the full 12 months it needs. One bottle is an expense. Twelve months is an investment.